Pubs

Mitsuhashi, M., Yamaguchi, R., Kawasaki, T., Ueno, S., Sun, Y., Isa, K., Takahashi, J., Kobayashi, K., Onoe, H., Takahashi, R., & Isa, T. (2024). Stage-dependent role of interhemispheric pathway for motor recovery in primates. Nature communications, 15(1), 6762. https://doi.org/10.1038/s41467-024-51070-w

Ryo Sasaki, Yasumi Ohta, Hirotaka Onoe, Reona Yamaguchi, Takeshi Miyamoto, Takashi Tokuda, Yuki Tamaki, Kaoru Isa, Jun Takahashi, Kenta Kobayashi, Jun Ohta, Tadashi Isa. Balancing Risk-Return Decisions by Manipulating the Mesofrontal Circuits in Primates. Science383,32-33(2024).

京都新聞：「生理学会発足100周年」インタビュー記事　2023.2.26「教育」掲載　

Okada T*, Handa S, Ding B, Urayama SI, Fujimoto K, Shima A, Yoshii D, Ayaki T, Sawamoto N, Takahashi R, Onoe H, Isa T, Petropoulos L. Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system. Magn Reson Med. 2022 Mar;87(3):1613-1620. Epub 2021 Nov 1.

Sawamura, M., Onoe, H., Tsukada, H., Isa, K., Yamakado, H., Okuda, S., Ikuno, M., Hatanaka, Y., Murayama, S., Uemura, N., Isa, T., & Takahashi, R. (2022). Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb. Movement disorders : official journal of the Movement Disorder Society, 37(10), 2033–2044.

Michiaki Suzuki,Ken-ichi Inoue,Hiroshi Nakagawa,Hiroaki Ishida,Kenta Kobayashi,Tadashi Isa,Masahiko Takada,Yukio Nishimura (2022) A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. Journal of Physiology,

Isa T (2021) Double viral vector intersectional approaches for pathway-selective manipulation of motor functions and compensatory mechanisms. Submitted to Experimental Neurology, Volume 349, 2022, 113959,

Isa K, Tokuoka K, Ikeda S, et al. Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus. Front Neural Circuits. 2022;15:768647. Published 2022 Jan 7.

Ohta Y, Guinto MC, Tokuda T, Kawahara M, Haruta M, Takehara H, Tashiro H, Sasagawa K, Onoe H, Yamaguchi R, Koshimizu Y, Isa K, Isa T, Kobayashi K, Akay YM, Akey M, Ohta J (2021) Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains. IEEE Access, vol. 9, pp. 127937-127949

Kasai M, Isa T (2021) Effects of light isoflurane anesthesia on organization of direction and orientation selectivity in the superficial layer of the mouse superior colliculus, Journal of Neuroscience, JN-RM-1196-21

Kato R, Zeghbib A, Redgrave P, Isa T (2021) Visual instrumental learning in blindsight monkeys. Scientific Reports 11, 14819.

Eberle H, Hayashi Y, Kurazume R, Takei T, An Q. Modeling of hyper-adaptability: from motor coordination to rehabilitation. Adv Robotics. 2021;1–16.

Isa T, Yoshida M (2021) Neural mechanism of blindsight in a macaque model. Neuroscience, (Forefront review), 469: 138-161.

Isa T, Marquez-Legorreta E, Grillner S, Scott EK (2021) The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action. Current Biology (review), VOLUME 31, ISSUE 11, PR741-R762

Liao Y-P, Urayama S, Isa T, Fukuyama H* (2021) Optimal Model Mapping for Intravoxal Incoherent Motion MRI. Frontiers in Human Neuroscience, 15:617152

Okada T*, Kuribayashi H, Kaiser LG, Urushibata Y, Salibi N, Seethamraju RT, Ahn S, Thuy DHD, Fujimoto K, Isa T (2021) Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison.Quant Imaging Med Surg. 11:9-20.

Kato R, Hayashi T, Onoe K, Yoshida M, Tsukada H, Onoe H, Isa T, Ikeda T (2021) The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques. Communications Biology, 4:278

Zubair M, Murris S, Isa K, Onoe H, Koshimizu Y, Kobayashi K, Vanduffel W*, Isa T* (2021) Divergent whole brain projections from the ventral midbrain in macaque monkeys. Cerebral Cortex, bhaa399.

Takakuwa N, Isa K, Onoe H, Takahashi J, Isa T* (2021) Contribution of the pulvinar and lateral geniculate nucleus to the control of visually guided saccades in blindsight monkeys. Journal of Neuroscience, 41(8):1755-1768.

Chen C-Y, Matrov D, Veale R, Onoe H, Yoshida M, Miura K, Isa T* (2021) Properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human. Journal of Neurophysiology, 125:437-457. 

Koshimizu Y, Isa K, Kobayashi K, Isa T (2021) Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety. Gene Therapy, 28:339-350. Epub 2021 Jan 11.

Yaron A, Kowalski D, Yaguchi H, Takei T, Seki K. Forelimb force direction and magnitude independently controlled by spinal modules in the macaque.
Proc Natl Acad Sci U S A. 2020 Oct 15:201919253. 

Tokuoka K, Kasai M, Kobayashi K, Isa T. Anatomical and electrophysiological analysis of cholinergic projections from the parabigeminal nucleus to the superficial superior colliculus. J Neurophysiol. 2020 Dec 1;124(6):1968-1985.

Aizawa H, Cui W, Aida T, Ito H, Kobayashi K, Wada Y, Kato S, Nakano T, Isa K, Kobayashi K, Isa T, Tanaka K (2020) Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress. Journal of Neuroscience,16 September 2020, 40 (38) 7241-7254;

Isa K, Sooksawate T, Kobayashi K, Kobayashi K, Redgrave P, Isa T (2020) Dissecting the tectal output channels for orienting and defense responses. eNeuro, 7(5) :ENEURO.0271-20.2020. 

Vancraeyenest P, Arsenault JT, Li X, Zhu Q, Kobayashi K, Isa K, Isa T, Vanduffel W (2020) Selective mesoaccumbal pathway inactivation affects motivation but not reinforcement-based learning in macaques. Neuron, in press

Kawamura A, Katayama Y, Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI (2020) Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Hum Mol Genet. 28;29(8):1274-1291.

Susaki EA, Shimizu C, Kuno A, Tainaka K, Li X, Nishi K, Morishima K, Ono H, Ode KL, Saeki Y, Miyamichi K, Isa K, Yokoyama C, Kitaura H, Ikemura M, Ushiku T, Shimizu Y, Saito T, Saido TC, Fukayama M, Onoe H, Touhara K, Isa T, Kakita A, Shibayama M, Ueda HR. (2020) Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues. Nat Commun. 27;11(1):1982.

Suzuki M, Onoe K, Sawada M, Takahashi N, Higo N, Murata Y, Tsukada YH, Isa T, Onoe H, Nishimura Y (2020) The ventral striatum is a key node of cortical reorganization required for functional recovery of finger dexterity after spinal cord injury in monkeys. Cerebral Cortex, 30:3259-3270. 

*Ryo Sasaki, Akiyuki Anzai, Dora E. Angelaki, Gregory C. DeAngelis; Flexible coding of object motion in multiple reference frames by parietal cortex neurons.;  Nat Neurosci. 2020 Aug;23(8):1004-1015. 

Oya T*, Takei T*, Seki K (*These authors contributed equally); Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip; Communications Biology; 2020 Apr 2

科学新聞;「脳出血後のリハビリで第２第３の神経活性化」多層の回復システム存在; 2019.9.20 掲載

Koide R, Yoshikawa R, Okamoto M, Sakaguchi S, Suzuki J, Isa T, Nakagawa S, Sakawaki H, Miura T, Miyazawa T; Experimental infection of Japanese macaques with simian retrovirus 5.; J Gen Virol; 2019 Feb

Kinoshita M, Kato R, Isa K, Kobayashi K, Kobayashi K, Onoe H, Isa T; Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus.; Nat Commun; 2019 Jan 11

Isa T; Dexterous Hand Movements and Their Recovery After Central Nervous System Injury.; Annu Rev Neurosci; 2019 Jul 8

Chao ZC, Sawada M, Isa T, Nishimura Y; Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys.; Cereb Cortex; 2019 Jul 5

Sugiyama Y, Oishi T, Yamashita A, Murata Y, Yamamoto T, Takashima I, Isa T, Higo N; Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques.; Brain Res; 2019 Jul 1

Urushibata Y, Kuribayashi H, Fujimoto K, Kober T, Grinstead JW, Isa T, Okada T; Advantages of fluid and white matter suppression (FLAWS) with MP2RAGE compared with double inversion recovery turbo spin echo (DIR-TSE) at 7T.; Eur J Radiol; 2019 Jul

Farrow K, Isa T, Luksch H, Yonehara K; Editorial: The Superior Colliculus/Tectum: Cell Types, Circuits, Computations, Behaviors.; Front Neural Circuits; 2019

Umeda T, Isa T, Nishimura Y; The somatosensory cortex receives information about motor output.; Sci Adv; 2019 Jul

Ishida A, Kobayashi K, Ueda Y, Shimizu T, Tajiri N, Isa T, Hida H; Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats.; J Neurosci; 2019 Sep 11

Isa T, Mitsuhashi M, Yamaguchi R; Alternative routes for recovery of hand functions after coticospinal tract injury in primates and rodents.; Curr Opin Neurol; 2019 Sep 20

Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H, Katoh T, Yamaguchi Y; Di-(2-Ethylhexyl) Phthalate Promotes Release of Tissue Factor-Bearing Microparticles From Macrophages via the TGFβ1/Smad/PAI-1 Signaling Pathway.; Am J Med Sci; 2019 Jun

Higo N, Sato A, Yamamoto T, Oishi T, Nishimura Y, Murata Y, Onoe H, Isa T, Kojima T; Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury.; J Comp Neurol; 2018 May 1

Wanasuntronwong A, Wanakhachornkrai O, Phongphanphanee P, Isa T, Tantisira B, Tantisira MH; Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233.; Evid Based Complement Alternat Med; 2018

Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR; Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.; Cell Rep; 2018 Aug 21

Takakuwa N, Redgrave P, Isa T; Cortical visual processing evokes short-latency reward-predicting cue responses in primate midbrain dopamine neurons.; Sci Rep; 2018 Oct 8

Beck RB, Kneafsey SL, Narasimham S, O’Riordan S, Isa T, Hutchinson M, Reilly RB; Reduced Frequency of Ipsilateral Express Saccades in Cervical Dystonia: Probing the Nigro-Tectal Pathway.; Tremor Other Hyperkinet Mov (N Y); 2018

Kawasaki T, Kurosaki Y, Fukuda H, Kinosada M, Ishibashi R, Handa A, Chin M, Yamagata S; Flexible endoscopically assisted evacuation of acute and subacute subdural hematoma through a small craniotomy: preliminary results.; Acta Neurochir (Wien); 2018 Feb

Koyanagi M, Fukuda H, Saiki M, Tsuji Y, Lo B, Kawasaki T, Ioroi Y, Fukumitsu R, Ishibashi R, Oda M, Narumi O, Chin M, Yamagata S, Miyamoto S; Effect of choice of treatment modality on the incidence of shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage.; J Neurosurg; 2018 Mar 9

Yoshida Y, Isa T; Neural and genetic basis of dexterous hand movements.; Curr Opin Neurobiol; 2018 Oct

Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H, Yamaguchi Y; Transcription factor specificity protein 1 modulates TGFβ1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P.; Cytokine; 2018 Aug

Sakamoto A, Yamaguchi R, Yamaguchi R, Narahara S, Sugiuchi H, Yamaguchi Y; Cross-talk between the transcription factor Sp1 and C/EBPβ modulates TGFβ1 production to negatively regulate the expression of chemokine RANTES.; Heliyon; 2018 Jul

Yamamoto T, Murayama S, Takao M, Isa T, Higo N; Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis.; Brain Res; 2017 Jan 15

Tohyama T, Kinoshita M, Kobayashi K, Isa K, Watanabe D, Kobayashi K, Liu M, Isa T; Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.; Proc Natl Acad Sci U S A; 2017 Jan 17

Yoshida M, Hafed ZM, Isa T; Informative Cues Facilitate Saccadic Localization in Blindsight Monkeys.; Front Syst Neurosci; 2017

Takakuwa N, Kato R, Redgrave P, Isa T; Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys.; Elife; 2017 Jun 19

Isa T; The Brain Is Needed to Cure Spinal Cord Injury.; Trends Neurosci; 2017 Oct

Isa T; Using the common marmoset for neurophysiological studies of neocortical functions.; J Physiol; 2017 Dec 1

Veale R, Hafed ZM, Yoshida M; How is visual salience computed in the brain? Insights from behaviour, neurobiology and modelling.; Philos Trans R Soc Lond B Biol Sci; 2017 Feb 19

Kawasaki T, Yoshida K, Kikuchi T, Ishii A, Takagi Y, Miyamoto S; Ruptured Aneurysms of the Occipital Artery Associated with Congenital Occipital Bone Defect.; World Neurosurg; 2017 Jan

Ishida A, Isa K, Umeda T, Kobayashi K, Kobayashi K, Hida H, Isa T; Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.; J Neurosci; 2016 Jan 13

Kobayashi K, Sano H, Kato S, Kuroda K, Nakamuta S, Isa T, Nambu A, Kaibuchi K, Kobayashi K; Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway.; Neurosci Lett; 2016 Sep 6

Kasai M, Isa T; Imaging population dynamics of surround suppression in the superior colliculus.; Eur J Neurosci; 2016 Oct

Yamaguchi R, Okamura JY, Wang G; Dynamics of population coding for object views following object discrimination training.; Neuroscience; 2016 Aug 25

Kawasaki T, Kitagawa M, Suzuki K, Wataya T; Chronic subdural hematoma associated with mucopolysaccharidosis type III B (Sanfilippo’s syndrome B).; Childs Nerv Syst; 2016 May

Amly, W. and Karaman, R; Recent updates in utilizing prodrugs in drug delivery (2013-2015); Expert Opinion Drug Delivery; 2016

Amly, W. and Karaman, R; Overview on the recent drugs delivery approaches. Aperito Journal of Pharmacology and Drug Design, 2; 2016

Amly W, Karaman R; Recent updates in utilizing prodrugs in drug delivery (2013-2015).; Expert Opin Drug Deliv; 2016

Murata Y, Higo N, Oishi T, Isa T; Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.; Neurosci Res; 2015 Sep

Yoshida M, Isa T; Signal detection analysis of blindsight in monkeys.; Sci Rep; 2015 May 29

Kondo T, Yoshihara Y, Yoshino-Saito K, Sekiguchi T, Kosugi A, Miyazaki Y, Nishimura Y, Okano HJ, Nakamura M, Okano H, Isa T, Ushiba J; Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.; Neurosci Res; 2015 Sep

Watanabe H, Takahashi K, Isa T; Phase locking of β oscillation in electrocorticography (ECoG) in the monkey motor cortex at the onset of EMGs and 3D reaching movements.; Conf Proc IEEE Eng Med Biol Soc; 2015

Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Sasaki T, Kasai M, Isa T, Kato G, Nabekura J, Mizukami H, Ozawa K, Kawasaki H, Yamamori T; In Vivo Two-Photon Imaging of Dendritic Spines in Marmoset Neocortex; eNeuro; 2015 Jul-Aug

Watakabe A, Ohtsuka M, Kinoshita M, Takaji M, Isa K, Mizukami H, Ozawa K, Isa T, Yamamori T; Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex.; Neurosci Res; 2015 Apr

Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H; Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys.; J Neurosci; 2015 Jan 7

Sawada M, Kato K, Kunieda T, Mikuni N, Miyamoto S, Onoe H, Isa T, Nishimura Y; Function of the nucleus accumbens in motor control during recovery after spinal cord injury.; Science; 2015 Oct 2

Mansouri FA, Buckley MJ, Mahboubi M, Tanaka K; Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices.; Proc Natl Acad Sci U S A; 2015 Jul 21

Isa T, Nishimura Y; Plasticity for recovery after partial spinal cord injury – hierarchical organization.; Neurosci Res; 2014 Jan

Phongphanphanee P, Marino RA, Kaneda K, Yanagawa Y, Munoz DP, Isa T; Distinct local circuit properties of the superficial and intermediate layers of the rodent superior colliculus.; Eur J Neurosci; 2014 Jul

Chen C, Shin D, Watanabe H, Nakanishi Y, Kambara H, Yoshimura N, Nambu A, Isa T, Nishimura Y, Koike Y; Decoding grasp force profile from electrocorticography signals in non-human primate sensorimotor cortex.; Neurosci Res; 2014 Jun

Hutchinson M, Isa T, Molloy A, Kimmich O, Williams L, Molloy F, Moore H, Healy DG, Lynch T, Walsh C, Butler J, Reilly RB, Walsh R, O’Riordan S; Cervical dystonia: a disorder of the midbrain network for covert attentional orienting.; Front Neurol; 2014

Umeda T, Watanabe H, Sato MA, Kawato M, Isa T, Nishimura Y; Decoding of the spike timing of primary afferents during voluntary arm movements in monkeys.; Front Neurosci; 2014

Watanabe H, Sakatani T, Suzuki T, Sato MA, Nishimura Y, Nambu A, Kawato M, Isa T; Reconstruction of intracortical whisker-evoked local field potential from electrocorticogram using a model trained for spontaneous activity in the rat barrel cortex.; Neurosci Res; 2014 Oct

Morishita S, Sato K, Watanabe H, Nishimura Y, Isa T, Kato R, Nakamura T, Yokoi H; Brain-machine interface to control a prosthetic arm with monkey ECoGs during periodic movements.; Front Neurosci; 2014

Watanabe H, Takahashi K, Nishimura Y, Isa T; Phase and magnitude spatiotemporal dynamics of β oscillation in electrocorticography (ECoG) in the monkey motor cortex at the onset of 3D reaching movements.; Conf Proc IEEE Eng Med Biol Soc; 2014

Yoshida M, Veale R; Saliency-guided neural prosthesis for visual attention: design and simulation.; Neurosci Res; 2014 Jan

Okamura JY, Yamaguchi R, Honda K, Wang G, Tanaka K; Neural substrates of view-invariant object recognition developed without experiencing rotations of the objects.; J Neurosci; 2014 Nov 5

Higo N, Isa T; Strategies to understand and overcome brain/spinal cord injury.; Neurosci Res; 2014 Jan

Wanakhachornkrai O, Umeda T, Isa K, Tantisira MH, Tantisira B, Isa T; Reorganization of sensory pathways after neonatal hemidecortication in rats.; Neurosci Res; 2014 Feb

Sugiyama Y, Higo N, Yoshino-Saito K, Murata Y, Nishimura Y, Oishi T, Isa T; Effects of early versus late rehabilitative training on manual dexterity after corticospinal tract lesion in macaque monkeys.; J Neurophysiol; 2013 Jun

Yamamoto T, Oishi T, Higo N, Murayama S, Sato A, Takashima I, Sugiyama Y, Nishimura Y, Murata Y, Yoshino-Saito K, Isa T, Kojima T; Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.; PLoS One; 2013

Sooksawate T, Isa K, Matsui R, Kato S, Kinoshita M, Kobayashi K, Watanabe D, Kobayashi K, Isa T; Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.; Front Neural Circuits; 2013

Isa T, Kinoshita M, Nishimura Y; Role of Direct vs. Indirect Pathways from the Motor Cortex to Spinal Motoneurons in the Control of Hand Dexterity.; Front Neurol; 2013 Nov 19

Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T; DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.; J Neurosci; 2013 Dec 11

Chen C, Shin D, Watanabe H, Nakanishi Y, Kambara H, Yoshimura N, Nambu A, Isa T, Nishimura Y, Koike Y; Prediction of hand trajectory from electrocorticography signals in primary motor cortex.; PLoS One; 2013

Karaman R, Amly W, Scrano L, Mecca G, Bufo SA; Computationally designed prodrugs of statins based on Kirby’s enzyme model.; J Mol Model; 2013 Sep

Kojima T, Higo N, Sato A, Oishi T, Nishimura Y, Yamamoto T, Murata Y, Yoshino-Saito K, Onoe H, Isa T; Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain.; Neurochem Res; 2013 Jan

Karaman, R., Amly, W., Scrano, L., Mecca, G. and Bufo, S. A; Computationally designed prodrugs of statins based on Kirby’s enzyme model; J Mol Model; 2013

Alstermark B, Isa T; Circuits for skilled reaching and grasping.; Annu Rev Neurosci; 2012

Watanabe H, Sato MA, Suzuki T, Nambu A, Nishimura Y, Kawato M, Isa T; Reconstruction of movement-related intracortical activity from micro-electrocorticogram array signals in monkey primary motor cortex.; J Neural Eng; 2012 Jun

Sooksawate T, Yanagawa Y, Isa T; Cholinergic responses in GABAergic and non-GABAergic neurons in the intermediate gray layer of mouse superior colliculus.; Eur J Neurosci; 2012 Aug

Kaneda K, Yanagawa Y, Isa T; Transient enhancement of inhibition following visual cortical lesions in the mouse superior colliculus.; Eur J Neurosci; 2012 Oct

Shin D, Watanabe H, Kambara H, Nambu A, Isa T, Nishimura Y, Koike Y; Prediction of muscle activities from electrocorticograms in primary motor cortex of primates.; PLoS One; 2012

Umeda T, Seki K, Sato MA, Nishimura Y, Kawato M, Isa T; Population coding of forelimb joint kinematics by peripheral afferents in monkeys.; PLoS One; 2012

Isa T; [The corticospinal tract and its role in motor control].; Brain Nerve; 2012 Nov

Nishimura Y, Isa T; Cortical and subcortical compensatory mechanisms after spinal cord injury in monkeys.; Exp Neurol; 2012 May

Yoshida M, Itti L, Berg DJ, Ikeda T, Kato R, Takaura K, White BJ, Munoz DP, Isa T; Residual attention guidance in blindsight monkeys watching complex natural scenes.; Curr Biol; 2012 Aug 7

Kinoshita M, Matsui R, Kato S, Hasegawa T, Kasahara H, Isa K, Watakabe A, Yamamori T, Nishimura Y, Alstermark B, Watanabe D, Kobayashi K, Isa T; Genetic dissection of the circuit for hand dexterity in primates.; Nature; 2012 Jul 12

Yamamoto T, Higo N, Sato A, Nishimura Y, Oishi T, Murata Y, Yoshino-Saito K, Isa T, Kojima T; SPP1 expression in spinal motor neurons of the macaque monkey.; Neurosci Res; 2011 Jan

Sooksawate T, Isa K, Behan M, Yanagawa Y, Isa T; Organization of GABAergic inhibition in the motor output layer of the superior colliculus.; Eur J Neurosci; 2011 Feb

Phongphanphanee P, Mizuno F, Lee PH, Yanagawa Y, Isa T, Hall WC; A circuit model for saccadic suppression in the superior colliculus.; J Neurosci; 2011 Feb 9

Takaura K, Yoshida M, Isa T; Neural substrate of spatial memory in the superior colliculus after damage to the primary visual cortex.; J Neurosci; 2011 Mar 16

Kaneda K, Kasahara H, Matsui R, Katoh T, Mizukami H, Ozawa K, Watanabe D, Isa T; Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin.; PLoS One; 2011 Apr 5

Kato R, Takaura K, Ikeda T, Yoshida M, Isa T; Contribution of the retino-tectal pathway to visually guided saccades after lesion of the primary visual cortex in monkeys.; Eur J Neurosci; 2011 Jun

Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T; Neural substrates for the motivational regulation of motor recovery after spinal-cord injury.; PLoS One; 2011

Umeda T, Isa T; Differential contributions of rostral and caudal frontal forelimb areas to compensatory process after neonatal hemidecortication in rats.; Eur J Neurosci; 2011 Nov

Ikeda T, Yoshida M, Isa T; Lesion of primary visual cortex in monkey impairs the inhibitory but not the facilitatory cueing effect on saccade.; J Cogn Neurosci; 2011 May

Yoshino-Saito K, Nishimura Y, Oishi T, Isa T. Quantitative inter-segmental and inter-laminar comparison of corticospinal projections from the forelimb area of the primary motor cortex of macaque monkeys. Neuroscience. 2010;171(4):1164-1179.

Isa T; [Change in functional connectivity between the primary motor cortex and nucleus accumbens during the recovery from a lesion of the corticospinal tract in monkeys].; Rinsho Shinkeigaku; 2010 Nov

Higo N, Sato A, Yamamoto T, Nishimura Y, Oishi T, Murata Y, Onoe H, Yoshino-Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T; SPP1 is expressed in corticospinal neurons of the macaque sensorimotor cortex.; J Comp Neurol; 2010 Jul 1

Umeda T, Takahashi M, Isa K, Isa T; Formation of descending pathways mediating cortical command to forelimb motoneurons in neonatally hemidecorticated rats.; J Neurophysiol; 2010 Sep

Perfiliev S, Isa T, Johnels B, Steg G, Wessberg J; Reflexive limb selection and control of reach direction to moving targets in cats, monkeys, and humans.; J Neurophysiol; 2010 Nov

Tsuboi F, Nishimura Y, Yoshino-Saito K, Isa T; Neuronal mechanism of mirror movements caused by dysfunction of the motor cortex.; Eur J Neurosci; 2010 Oct

Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y; Different pedunculopontine tegmental neurons signal predicted and actual task rewards.; J Neurosci; 2009 Apr 15

Tanaka H, Ma J, Tanaka KF, Takao K, Komada M, Tanda K, Suzuki A, Ishibashi T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka K; Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities.; J Neurosci; 2009 Jul 1

Higo N, Nishimura Y, Murata Y, Oishi T, Yoshino-Saito K, Takahashi M, Tsuboi F, Isa T; Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract.; J Comp Neurol; 2009 Oct 20

Isa T, Hall WC; Exploring the superior colliculus in vitro.; J Neurophysiol; 2009 Nov

Nishimura Y, Isa T; Compensatory changes at the cerebral cortical level after spinal cord injury.; Neuroscientist; 2009 Oct

Isa T, Fetz EE, Müller KR; Recent advances in brain-machine interfaces.; Neural Netw; 2009 Nov

Takahashi M, Vattanajun A, Umeda T, Isa K, Isa T; Large-scale reorganization of corticofugal fibers after neonatal hemidecortication for functional restoration of forelimb movements.; Eur J Neurosci; 2009 Nov

Isa T, Yamane I, Hamai M, Inagaki H; Japanese macaques as laboratory animals.; Exp Anim; 2009 Oct

Isa T, Yoshida M; Saccade control after V1 lesion revisited.; Curr Opin Neurobiol; 2009 Dec

Yamazaki Y, Akashi R, Banno Y, Endo T, Ezura H, Fukami-Kobayashi K, Inaba K, Isa T, Kamei K, Kasai F, Kobayashi M, Kurata N, Kusaba M, Matuzawa T, Mitani S, Nakamura T, Nakamura Y, Nakatsuji N, Naruse K, Niki H, Nitasaka E, Obata Y, Okamoto H, Okuma M, Sato K, Serikawa T, Shiroishi T, Sugawara H, Urushibara H, Yamamoto M, Yaoita Y, Yoshiki A, Kohara Y; NBRP databases: databases of biological resources in Japan.; Nucleic Acids Res; 2010 Jan

Isa T; [Reconsidering somatotopy with respect to functional recovery from spinal cord injury].; Brain Nerve; 2009 Dec

Buckley MJ, Mansouri FA, Hoda H, Mahboubi M, Browning PG, Kwok SC, Phillips A, Tanaka K; Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.; Science; 2009 Jul 3

Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T; Regulation of burst activity through presynaptic and postsynaptic GABA(B) receptors in mouse superior colliculus.; J Neurosci; 2008 Jan 23

Endo T, Tarusawa E, Notomi T, Kaneda K, Hirabayashi M, Shigemoto R, Isa T; Dendritic Ih ensures high-fidelity dendritic spike responses of motion-sensitive neurons in rat superior colliculus.; J Neurophysiol; 2008 May

Sooksawate T, Isa K, Isa T; Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus.; J Neurophysiol; 2008 Nov

Phongphanphanee P, Kaneda K, Isa T; Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording.; J Neurosci; 2008 Sep 10

Yoshida M, Takaura K, Kato R, Ikeda T, Isa T; Striate cortical lesions affect deliberate decision and control of saccade: implication for blindsight.; J Neurosci; 2008 Oct 15

Kaneda K, Isa K, Yanagawa Y, Isa T; Nigral inhibition of GABAergic neurons in mouse superior colliculus.; J Neurosci; 2008 Oct 22

Nishimura Y, Isa T; [Brain mechanism for functional recovery of finger dexterity after spinal cord injury].; Nihon Ronen Igakkai Zasshi; 2008 Sep

Nishimura Y, Morichika Y, Isa T; A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury.; Brain; 2009 Mar

Isa T, Schwartz A; Motor systems. Introduction.; Curr Opin Neurobiol; 2008 Dec

Tsuji S, Isa T, Kato T, Mizusawa H, Takahashi T, Kato Y, Todo T; [Roundtable discussion: advances in neuroscience and therapeutic research on neurological diseases–the present status and future prospects].; No To Shinkei; 2007 Jan

Tsuji S, Isa T, Kato T, Mizusawa H, Takahashi T, Kato Y, Todo T, Okabe S; [Advances in neuroscience and therapeutic research on neurological diseases–the present status and future prospects (discussion)].; Brain Nerve; 2007 Jan

Isa T, Ohki Y, Alstermark B, Pettersson LG, Sasaki S; Direct and indirect cortico-motoneuronal pathways and control of hand/arm movements.; Physiology (Bethesda); 2007 Apr

Lee PH, Sooksawate T, Yanagawa Y, Isa K, Isa T, Hall WC; Identity of a pathway for saccadic suppression.; Proc Natl Acad Sci U S A; 2007 Apr 17

Sakatani T, Isa T; Quantitative analysis of spontaneous saccade-like rapid eye movements in C57BL/6 mice.; Neurosci Res; 2007 Jul

Nishimura Y, Isa T; [Neuronal mechanism of functional recovery of dexterous finger movements after lesion of the corticospinal tract–studies in a non-human primate model].; Brain Nerve; 2007 May

Nishimura Y, Onoe H, Morichika Y, Tsukada H, Isa T; Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys.; Neurosci Res; 2007 Nov

Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T; Differentially expressed genes among motor and prefrontal areas of macaque neocortex.; Biochem Biophys Res Commun; 2007 Oct 26

Nishimura Y, Onoe H, Morichika Y, Perfiliev S, Tsukada H, Isa T; Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.; Science; 2007 Nov 16

Isa T, Ohki Y, Seki K, Alstermark B; Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey.; J Neurophysiol; 2006 Jun

Tanaka H, Ikenaka K, Isa T; Electrophysiological abnormalities precede apparent histological demyelination in the central nervous system of mice overexpressing proteolipid protein.; J Neurosci Res; 2006 Nov 1

Sooksawate T, Isa T; Properties of cholinergic responses in neurons in the intermediate grey layer of rat superior colliculus.; Eur J Neurosci; 2006 Dec

Kurio S, Isa T; [New guidelines and standards in revised Animal Rights Act].; Nihon Seirigaku Zasshi; 2006

Saito Y, Isa T; Organization of interlaminar interactions in the rat superior colliculus.; J Neurophysiol; 2005 May

Sooksawate T, Saito Y, Isa T; Electrophysiological and morphological properties of identified crossed tecto-reticular neurons in the rat superior colliculus.; Neurosci Res; 2005 Jun

Endo T, Yanagawa Y, Obata K, Isa T; Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.; J Neurophysiol; 2005 Dec

Isa T, Kobayashi Y; Switching between cortical and subcortical sensorimotor pathways.; Prog Brain Res; 2004

Kobayashi Y, Inoue Y, Isa T; Pedunculo-pontine control of visually guided saccades.; Prog Brain Res; 2004

Yamashita T, Isa T; Enhancement of excitatory postsynaptic potentials by preceding application of acetylcholine in mesencephalic dopamine neurons.; Neurosci Res; 2004 May

Tanaka H, Ono K, Shibasaki H, Isa T, Ikenaka K; Conduction properties of identified neural pathways in the central nervous system of mice in vivo.; Neurosci Res; 2004 May

Sakatani T, Isa T; PC-based high-speed video-oculography for measuring rapid eye movements in mice.; Neurosci Res; 2004 May

Saitoh K, Isa T, Takakusaki K; Nigral GABAergic inhibition upon mesencephalic dopaminergic cell groups in rats.; Eur J Neurosci; 2004 May

Sasaki S, Isa T, Pettersson LG, Alstermark B, Naito K, Yoshimura K, Seki K, Ohki Y; Dexterous finger movements in primate without monosynaptic corticomotoneuronal excitation.; J Neurophysiol; 2004 Nov

Saito Y, Isa T; Laminar specific distribution of lateral excitatory connections in the rat superior colliculus.; J Neurophysiol; 2004 Dec

Watanabe M, Kobayashi Y, Inoue Y, Isa T; Effects of local nicotinic activation of the superior colliculus on saccades in monkeys.; J Neurophysiol; 2005 Jan

Li F, Endo T, Isa T; Presynaptic muscarinic acetylcholine receptors suppress GABAergic synaptic transmission in the intermediate grey layer of mouse superior colliculus.; Eur J Neurosci; 2004 Oct

Katsuta H, Isa T; Release from GABA(A) receptor-mediated inhibition unmasks interlaminar connection within superior colliculus in anesthetized adult rats.; Neurosci Res; 2003 May

Saito Y, Isa T; Local excitatory network and NMDA receptor activation generate a synchronous and bursting command from the superior colliculus.; J Neurosci; 2003 Jul 2

Endo T, Yanagawa Y, Obata K, Isa T; Characteristics of GABAergic neurons in the superficial superior colliculus in mice.; Neurosci Lett; 2003 Jul 31

Yamashita T, Isa T; Fulfenamic acid sensitive, Ca(2+)-dependent inward current induced by nicotinic acetylcholine receptors in dopamine neurons.; Neurosci Res; 2003 Aug

Saitoh K, Hattori S, Song WJ, Isa T, Takakusaki K; Nigral GABAergic inhibition upon cholinergic neurons in the rat pedunculopontine tegmental nucleus.; Eur J Neurosci; 2003 Aug

Yamashita T, Isa T; Ca2+-dependent inward current induced by nicotinic receptor activation depends on Ca2+/calmodulin-CaMKII pathway in dopamine neurons.; Neurosci Res; 2003 Oct

Endo T, Isa T; Postsynaptic and presynaptic GABA(B) receptor-mediated inhibition in rat superficial superior colliculus neurons.; Neurosci Lett; 2002 Apr 5

Isa T, Sasaki S; Brainstem control of head movements during orienting; organization of the premotor circuits.; Prog Neurobiol; 2002 Mar

Kobayashi Y, Inoue Y, Yamamoto M, Isa T, Aizawa H; Contribution of pedunculopontine tegmental nucleus neurons to performance of visually guided saccade tasks in monkeys.; J Neurophysiol; 2002 Aug

Alstermark B, Isa T; Premotoneuronal and direct corticomotoneuronal control in the cat and macaque monkey.; Adv Exp Med Biol; 2002

Kobayashi Y, Isa T; Sensory-motor gating and cognitive control by the brainstem cholinergic system.; Neural Netw; 2002 Jun-Jul

Isa T; Intrinsic processing in the mammalian superior colliculus.; Curr Opin Neurobiol; 2002 Dec