Our laboratory initially started in 1996, when Tadsahi Isa was assigned as a professor in the National Institute for Physiological Sciences in Okazaki, Aichi.

Researches were initiated to clarify the structure and functions of the neural curtuits controlling eye movement and dexterous hand movements and further progressed tounderstanding the neuronal mechanism of functional recovery after the brain and spinal cord injury using macaque monkey model, the closest experimental animal species to humans by combining multidisciplinary approached such as electrophysiology, neuroanatomy, non-invasive neuroimaging, Ca2+-imaging with 2-photon laser scanning microscope or endoscope system, circuit manipulation with viral vectors (optogenetics and chemo-genetics) and large-scaled data analysis using machine learning such as decoding and dimension reduction, psychophysics and behavioral analysis.

Moreover, we are studying the cognitive functions such as motivation, decision making, attention and consciousness, which are related to the processes of motor control and functional recovery.

We moved to Kyoto University in 2016 and started the new laboratory, and currently initiating a new project on the origin of evolution of the brain and its species differences as a member of Institute for the Advanced Study if Human Biology (WPI-ASHBi) of Kyoto University.

Selected Recent

Chen C-Y, Matrov D, Veale R, Onoe H, Yoshida M, Miura K, Isa T* (2021) Properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human. Journal of Neurophysiology, 125:437-457. 

Vancraeyenest P, Arsenault JT, Li X, Zhu Q, Kobayashi K, Isa K, Isa T, Vanduffel W (2020) Selective mesoaccumbal pathway inactivation affects motivation but not reinforcement-based learning in macaques. Neuron, in press

Kinoshita M, Kato R, Isa K, Kobayashi K, Kobayashi K, Onoe H, Isa T; Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus.; Nat Commun; 2019 Jan 11

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