Project 01 Recovery from brain & spinal cord injury
Project 02 Neural mechanism of blindsight
Project 03 Neural mechanism of flexible decision making
Project 04 Eye movement and attention systems in common marmosets
Project 05 Structure and function of the superior colliculus
Project 06 Development of selective circuit manipulation techniques
Project 07 Other projects -1-
Project 08 Other projects -2-
Our laboratory initially started in 1996, when Tadsahi Isa was assigned as a professor in the National Institute for Physiological Sciences in Okazaki, Aichi.
Researches were initiated to clarify the structure and functions of the neural curtuits controlling eye movement and dexterous hand movements and further progressed tounderstanding the neuronal mechanism of functional recovery after the brain and spinal cord injury using macaque monkey model, the closest experimental animal species to humans by combining multidisciplinary approached such as electrophysiology, neuroanatomy, non-invasive neuroimaging, Ca2+-imaging with 2-photon laser scanning microscope or endoscope system, circuit manipulation with viral vectors (optogenetics and chemo-genetics) and large-scaled data analysis using machine learning such as decoding and dimension reduction, psychophysics and behavioral analysis.
Moreover, we are studying the cognitive functions such as motivation, decision making, attention and consciousness, which are related to the processes of motor control and functional recovery.
We moved to Kyoto University in 2016 and started the new laboratory, and currently initiating a new project on the origin of evolution of the brain and its species differences as a member of Institute for the Advanced Study if Human Biology (WPI-ASHBi) of Kyoto University.
Okada T*, Handa S, Ding B, Urayama SI, Fujimoto K, Shima A, Yoshii D, Ayaki T, Sawamoto N, Takahashi R, Onoe H, Isa T, Petropoulos L. Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system. Magn Reson Med. 2022 Mar;87(3):1613-1620. Epub 2021 Nov 1.
Sawamura, M., Onoe, H., Tsukada, H., Isa, K., Yamakado, H., Okuda, S., Ikuno, M., Hatanaka, Y., Murayama, S., Uemura, N., Isa, T., & Takahashi, R. (2022). Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb. Movement disorders : official journal of the Movement Disorder Society, 37(10), 2033–2044.
Isa K, Tokuoka K, Ikeda S, et al. Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus. Front Neural Circuits. 2022;15:768647. Published 2022 Jan 7.