Recovery from brain & spinal cord injury
Using a macaque monkey model with lesion of the corticospinal tract is transected at the cervical cord, we are studying the neural mechanism of large-scaled neural network reorganization for recovery of dexterous hand movements which spans not only the spinal cord, but also bilateral motor cortices and even the meso-limbic structures such as the nucleus accumbens.
Suzuki M, Onoe K, Sawada M, Takahashi N, Higo N, Murata Y, Tsukada YH, Isa T, Onoe H, Nishimura Y (2020) The ventral striatum is a key node of cortical reorganization required for functional recovery of finger dexterity after spinal cord injury in monkeys. Cerebral Cortex, 30:3259-3270.
Chao ZC, Sawada M, Isa T, Nishimura Y; Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys.; Cereb Cortex; 2019 Jul 5
Tohyama T, Kinoshita M, Kobayashi K, Isa K, Watanabe D, Kobayashi K, Liu M, Isa T; Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.; Proc Natl Acad Sci U S A; 2017 Jan 17