Projects

Umeda T, Yokoyama O, Suzuki M, Kaneshige M, Isa T, Nishimura Y (2024) Future spinal reflex is embedded in primary motor cortex output. Science Advances, 10(51): eadq4194. doi: 10.1126/sciadv.adq4194.

Ueno, S., Yamaguchi, R., Isa, K., Kawasaki, T., Mitsuhashi, M., Kobayashi, K., Takahashi, J., & Isa, T. (2024). Supraspinal Plasticity of Axonal Projections From the Motor Cortex After Spinal Cord Injury in Macaques. The Journal of comparative neurology, 532(12), e70007. https://doi.org/10.1002/cne.70007

Mitsuhashi, M., Yamaguchi, R., Kawasaki, T., Ueno, S., Sun, Y., Isa, K., Takahashi, J., Kobayashi, K., Onoe, H., Takahashi, R., & Isa, T. (2024). Stage-dependent role of interhemispheric pathway for motor recovery in primates. Nature communications, 15(1), 6762. https://doi.org/10.1038/s41467-024-51070-w

Sawada M, Yoshino-Saito K, Ninomiya T, Oishi T, Yamashita T, Onoe H, Takada M, Nishimura Y, Isa T (2023) Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys. eNeuro, 10(8):ENEURO.0209-23.2023.

Isa T, Tohyama T, Kinoshita M (2022) Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury. Current research in Neurobiology, 3:100058.

Suzuki M, Onoe K, Sawada M, Takahashi N, Higo N, Murata Y, Tsukada YH, Isa T, Onoe H, Nishimura Y (2020) The ventral striatum is a key node of cortical reorganization required for functional recovery of finger dexterity after spinal cord injury in monkeys. Cerebral Cortex, 30:3259-3270. 

Chao ZC, Sawada M, Isa T, Nishimura Y; Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys.; Cereb Cortex; 2019 Jul 5

Tohyama T, Kinoshita M, Kobayashi K, Isa K, Watanabe D, Kobayashi K, Liu M, Isa T; Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.; Proc Natl Acad Sci U S A; 2017 Jan 17

Sawada M, Kato K, Kunieda T, Mikuni N, Miyamoto S, Onoe H, Isa T, Nishimura Y; Function of the nucleus accumbens in motor control during recovery after spinal cord injury.; Science; 2015 Oct 2

Ryo Sasaki, Yasumi Ohta, Hirotaka Onoe, Reona Yamaguchi, Takeshi Miyamoto, Takashi Tokuda, Yuki Tamaki, Kaoru Isa, Jun Takahashi, Kenta Kobayashi, Jun Ohta, Tadashi Isa. Balancing Risk-Return Decisions by Manipulating the Mesofrontal Circuits in Primates. Science383,32-33(2024).

Takakuwa N, Redgrave P, Isa T; Cortical visual processing evokes short-latency reward-predicting cue responses in primate midbrain dopamine neurons.; Sci Rep; 2018 Oct 8

Takakuwa N, Kato R, Redgrave P, Isa T; Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys.; Elife; 2017 Jun 19

Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y; Different pedunculopontine tegmental neurons signal predicted and actual task rewards.; J Neurosci; 2009 Apr 15

Kasai M, Isa T (2021) Effects of light isoflurane anesthesia on organization of direction and orientation selectivity in the superficial layer of the mouse superior colliculus, Journal of Neuroscience, JN-RM-1196-21

Tokuoka K, Kasai M, Kobayashi K, Isa T. Anatomical and electrophysiological analysis of cholinergic projections from the parabigeminal nucleus to the superficial superior colliculus. J Neurophysiol. 2020 Dec 1;124(6):1968-1985.

Isa K, Sooksawate T, Kobayashi K, Kobayashi K, Redgrave P, Isa T (2020) Dissecting the tectal output channels for orienting and defense responses. eNeuro, 7(5) :ENEURO.0271-20.2020. 

Kasai M, Isa T; Imaging population dynamics of surround suppression in the superior colliculus.; Eur J Neurosci; 2016 Oct

Phongphanphanee P, Marino RA, Kaneda K, Yanagawa Y, Munoz DP, Isa T; Distinct local circuit properties of the superficial and intermediate layers of the rodent superior colliculus.; Eur J Neurosci; 2014 Jul