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Amly W, Chen C-Y, Onoe H, Isa T (2025) Different Properties of Successful and Error Saccades in Marmosets. Neuroscience Research.

Umeda T, Yokoyama O, Suzuki M, Kaneshige M, Isa T, Nishimura Y (2024) Future spinal reflex is embedded in primary motor cortex output. Science Advances, 10(51): eadq4194. doi: 10.1126/sciadv.adq4194.

Amly, W., Chen, C. Y., & Isa, T. (2024). Modeling saccade reaction time in marmosets: the contribution of earlier visual response and variable inhibition. Frontiers in systems neuroscience, 18, 1478019. https://doi.org/10.3389/fnsys.2024.1478019

Ueno, S., Yamaguchi, R., Isa, K., Kawasaki, T., Mitsuhashi, M., Kobayashi, K., Takahashi, J., & Isa, T. (2024). Supraspinal Plasticity of Axonal Projections From the Motor Cortex After Spinal Cord Injury in Macaques. The Journal of comparative neurology, 532(12), e70007. https://doi.org/10.1002/cne.70007

Mitsuhashi, M., Yamaguchi, R., Kawasaki, T., Ueno, S., Sun, Y., Isa, K., Takahashi, J., Kobayashi, K., Onoe, H., Takahashi, R., & Isa, T. (2024). Stage-dependent role of interhemispheric pathway for motor recovery in primates. Nature communications, 15(1), 6762. https://doi.org/10.1038/s41467-024-51070-w

Kuribayashi H, Urushibata Y, Imai H, Ahn S, Seethamraju RT, Isa T, Okada T (2023) Quantification of Cerebral Glucose Concentrations via Detection of the H1-α-Glucose Peak in H MRS at 7 T. J Magn Reson Imaging, 59:661-672.

Sawada M, Yoshino-Saito K, Ninomiya T, Oishi T, Yamashita T, Onoe H, Takada M, Nishimura Y, Isa T (2023) Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys. eNeuro, 10(8):ENEURO.0209-23.2023.

Takahashi M, Kobayashi T, Mizuma H, Yamauchi K, Okamoto S, Okamoto K, Ishida Y, Koike M, Watanabe M, Isa T, Hioki H (2023) Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum. Neuroscience Research, 190:92-106.

Takakuwa N, Isa T (2023) Visuomotor coordination and cognitive capacity in blindsight. Current Opinion in Neurobiology, 82:102764.

Yu X, Yamaguchi R, Isa T (2023) How to study subjective experience in an animal model of blindsight? Neuroscience Research, 201:39-45

Yamauchi K, Okamoto S, Ishida Y, Konno K, Hoshino K, Furuta T, Takahashi M, Koike M, Isa K, Watanabe M, Isa T, Hioki H (2022) Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis. Scientific Reports,12(1):14807.

Okada T, Handa S, Ding B, Urayama SI, Fujimoto K, Shima A, Yoshii D, Ayaki T, Sawamoto N, Takahashi R, Onoe H, Isa T, Petropoulos L (2022) Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system. Magn Reson Med. 87: 1613-1620. 

Tsujihana K, Tanegashima K, Santo Y, Yamada H, Akazawa S, Nakao R, Tominaga K, Saito R, Nishito Y, Hata RI, Nakamura T, Murai I, Kono Y, Sugawa M, Tanioka M, Egawa G, Doi M, Isa T, Kabashima K, Hara T, Okamura H (2022) Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity. Proceedings of National Academy of Science USA, 119(25): e2116027119.

Umeda T, Isa T, Nishimura Y (2022) Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement. Proceedings of National Academy of Science USA, 119(48): e2208353119.

Takakuwa N, Isa K, Yamaguchi R, Onoe H, Takahashi J, Yoshida M, Isa T (2022) Protocol for making an animal model of “blindsight” in macaque monkeys. STAR Protocols, 4(1):101960

Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy DHD, Shima A, Sawamoto N, Oishi N, Zhang Z, Funaki T, Nakamoto Y, Murai T, Miyamoto S, Takahashi R, Isa T (2022) Neuroimaging at 7 Tesla: a pictorial narrative review. Quant Imaging Med Surg, 12(6):3406-3435.

Janssen P, Isa T, Lanciego J, Leech K, Logothetis, N, Poo M-M, Mitchell A (2022) Visualizing advances in the future of primate neuroscience research. Current Research in Neurobiology, 13;4:100064.

Isa T, Tohyama T, Kinoshita M (2022) Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury. Current research in Neurobiology, 3:100058.

Sawamura, M., Onoe, H., Tsukada, H., Isa, K., Yamakado, H., Okuda, S., Ikuno, M., Hatanaka, Y., Murayama, S., Uemura, N., Isa, T., & Takahashi, R. (2022). Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb. Movement disorders : official journal of the Movement Disorder Society, 37(10), 2033–2044.

Okada T*, Handa S, Ding B, Urayama SI, Fujimoto K, Shima A, Yoshii D, Ayaki T, Sawamoto N, Takahashi R, Onoe H, Isa T, Petropoulos L. Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system. Magn Reson Med. 2022 Mar;87(3):1613-1620. Epub 2021 Nov 1.

Michiaki Suzuki,Ken-ichi Inoue,Hiroshi Nakagawa,Hiroaki Ishida,Kenta Kobayashi,Tadashi Isa,Masahiko Takada,Yukio Nishimura (2022) A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. Journal of Physiology,

Isa T (2022) Double viral vector intersectional approaches for pathway-selective manipulation of motor functions and compensatory mechanisms. Submitted to Experimental Neurology, Volume 349, 2022, 113959,

Isa K, Tokuoka K, Ikeda S, et al. Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus. Front Neural Circuits. 2022;15:768647. Published 2022 Jan 7.

Kasai M, Isa T (2021) Effects of light isoflurane anesthesia on organization of direction and orientation selectivity in the superficial layer of the mouse superior colliculus, Journal of Neuroscience, JN-RM-1196-21

Ohta Y, Guinto MC, Tokuda T, Kawahara M, Haruta M, Takehara H, Tashiro H, Sasagawa K, Onoe H, Yamaguchi R, Koshimizu Y, Isa K, Isa T, Kobayashi K, Akay YM, Akey M, Ohta J (2021) Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains. IEEE Access, vol. 9, pp. 127937-127949

Kato R, Zeghbib A, Redgrave P, Isa T (2021) Visual instrumental learning in blindsight monkeys. Scientific Reports 11, 14819.

Isa T, Yoshida M (2021) Neural mechanism of blindsight in a macaque model. Neuroscience, (Forefront review), 469: 138-161.

Liao Y-P, Urayama S, Isa T, Fukuyama H* (2021) Optimal Model Mapping for Intravoxal Incoherent Motion MRI. Frontiers in Human Neuroscience, 15:617152

Okada T*, Kuribayashi H, Kaiser LG, Urushibata Y, Salibi N, Seethamraju RT, Ahn S, Thuy DHD, Fujimoto K, Isa T (2021) Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison.Quant Imaging Med Surg. 11:9-20.

Kato R, Hayashi T, Onoe K, Yoshida M, Tsukada H, Onoe H, Isa T, Ikeda T (2021) The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques. Communications Biology, 4:278

Zubair M, Murris S, Isa K, Onoe H, Koshimizu Y, Kobayashi K, Vanduffel W*, Isa T* (2021) Divergent whole brain projections from the ventral midbrain in macaque monkeys. Cerebral Cortex, bhaa399.

Takakuwa N, Isa K, Onoe H, Takahashi J, Isa T* (2021) Contribution of the pulvinar and lateral geniculate nucleus to the control of visually guided saccades in blindsight monkeys. Journal of Neuroscience, 41(8):1755-1768.

Chen C-Y, Matrov D, Veale R, Onoe H, Yoshida M, Miura K, Isa T* (2021) Properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human. Journal of Neurophysiology, 125:437-457. 

Koshimizu Y, Isa K, Kobayashi K, Isa T (2021) Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety. Gene Therapy, 28:339-350. Epub 2021 Jan 11.

Tokuoka K, Kasai M, Kobayashi K, Isa T. Anatomical and electrophysiological analysis of cholinergic projections from the parabigeminal nucleus to the superficial superior colliculus. J Neurophysiol. 2020 Dec 1;124(6):1968-1985.

Aizawa H, Cui W, Aida T, Ito H, Kobayashi K, Wada Y, Kato S, Nakano T, Isa K, Kobayashi K, Isa T, Tanaka K (2020) Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress. Journal of Neuroscience,16 September 2020, 40 (38) 7241-7254;

Isa K, Sooksawate T, Kobayashi K, Kobayashi K, Redgrave P, Isa T (2020) Dissecting the tectal output channels for orienting and defense responses. eNeuro, 7(5) :ENEURO.0271-20.2020. 

Vancraeyenest P, Arsenault JT, Li X, Zhu Q, Kobayashi K, Isa K, Isa T, Vanduffel W (2020) Selective mesoaccumbal pathway inactivation affects motivation but not reinforcement-based learning in macaques. Neuron, in press

Kawamura A, Katayama Y, Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI (2020) Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Hum Mol Genet. 28;29(8):1274-1291.

Susaki EA, Shimizu C, Kuno A, Tainaka K, Li X, Nishi K, Morishima K, Ono H, Ode KL, Saeki Y, Miyamichi K, Isa K, Yokoyama C, Kitaura H, Ikemura M, Ushiku T, Shimizu Y, Saito T, Saido TC, Fukayama M, Onoe H, Touhara K, Isa T, Kakita A, Shibayama M, Ueda HR. (2020) Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues. Nat Commun. 27;11(1):1982.

Suzuki M, Onoe K, Sawada M, Takahashi N, Higo N, Murata Y, Tsukada YH, Isa T, Onoe H, Nishimura Y (2020) The ventral striatum is a key node of cortical reorganization required for functional recovery of finger dexterity after spinal cord injury in monkeys. Cerebral Cortex, 30:3259-3270. 

科学新聞;「脳出血後のリハビリで第２第３の神経活性化」多層の回復システム存在; 2019.9.20 掲載

Kinoshita M, Kato R, Isa K, Kobayashi K, Kobayashi K, Onoe H, Isa T; Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus.; Nat Commun; 2019 Jan 11

Isa T; Dexterous hand movements and their recovery after central nervous system injury.; Annual Review of Neuroscience; 2019, 42:315-335

Chao ZC, Sawada M, Isa T, Nishimura Y; Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys.; Cereb Cortex; 2019 Jul 5

Sugiyama Y, Oishi T, Yamashita A, Murata Y, Yamamoto T, Takashima I, Isa T, Higo N; Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques.; Brain Res; 2019 Jul 1

Umeda T, Isa T, Nishimura Y; The somatosensory cortex receives information about motor output.; Sci Adv; 2019 Jul

Isa T, Mitsuhashi M, Yamaguchi R; Alternative routes for recovery of hand functions after coticospinal tract injury in primates and rodents.; Curr Opin Neurol; 2019 Sep 20

Wanasuntronwong A, Wanakhachornkrai O, Phongphanphanee P, Isa T, Tantisira B, Tantisira MH; Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233.; Evid Based Complement Alternat Med; 2018

Takakuwa N, Redgrave P, Isa T; Cortical visual processing evokes short-latency reward-predicting cue responses in primate midbrain dopamine neurons.; Sci Rep; 2018 Oct 8

Yoshida Y, Isa T; Neural and genetic basis of dexterous hand movements.; Curr Opin Neurobiol; 2018 Oct

Tohyama T, Kinoshita M, Kobayashi K, Isa K, Watanabe D, Kobayashi K, Liu M, Isa T; Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.; Proc Natl Acad Sci U S A; 2017 Jan 17

Takakuwa N, Kato R, Redgrave P, Isa T; Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys.; Elife; 2017 Jun 19

Kasai M, Isa T; Imaging population dynamics of surround suppression in the superior colliculus.; Eur J Neurosci; 2016 Oct

Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Sasaki T, Kasai M, Isa T, Kato G, Nabekura J, Mizukami H, Ozawa K, Kawasaki H, Yamamori T; In Vivo Two-Photon Imaging of Dendritic Spines in Marmoset Neocortex; eNeuro; 2015 Jul-Aug

Watakabe A, Ohtsuka M, Kinoshita M, Takaji M, Isa K, Mizukami H, Ozawa K, Isa T, Yamamori T; Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex.; Neurosci Res; 2015 Apr

Sawada M, Kato K, Kunieda T, Mikuni N, Miyamoto S, Onoe H, Isa T, Nishimura Y; Function of the nucleus accumbens in motor control during recovery after spinal cord injury.; Science; 2015 Oct 2

Phongphanphanee P, Marino RA, Kaneda K, Yanagawa Y, Munoz DP, Isa T; Distinct local circuit properties of the superficial and intermediate layers of the rodent superior colliculus.; Eur J Neurosci; 2014 Jul

Sooksawate T, Isa K, Matsui R, Kato S, Kinoshita M, Kobayashi K, Watanabe D, Kobayashi K, Isa T; Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.; Front Neural Circuits; 2013

Isa T, Kinoshita M, Nishimura Y; Role of Direct vs. Indirect Pathways from the Motor Cortex to Spinal Motoneurons in the Control of Hand Dexterity.; Front Neurol; 2013 Nov 19

Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T; DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.; J Neurosci; 2013 Dec 11

Yoshida M, Itti L, Berg DJ, Ikeda T, Kato R, Takaura K, White BJ, Munoz DP, Isa T; Residual attention guidance in blindsight monkeys watching complex natural scenes.; Curr Biol; 2012 Aug 7

Kinoshita M, Matsui R, Kato S, Hasegawa T, Kasahara H, Isa K, Watakabe A, Yamamori T, Nishimura Y, Alstermark B, Watanabe D, Kobayashi K, Isa T; Genetic dissection of the circuit for hand dexterity in primates.; Nature; 2012 Jul 12

Phongphanphanee P, Mizuno F, Lee PH, Yanagawa Y, Isa T, Hall WC; A circuit model for saccadic suppression in the superior colliculus.; J Neurosci; 2011 Feb 9

Kato R, Takaura K, Ikeda T, Yoshida M, Isa T; Contribution of the retino-tectal pathway to visually guided saccades after lesion of the primary visual cortex in monkeys.; Eur J Neurosci; 2011 Jun

Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y; Different pedunculopontine tegmental neurons signal predicted and actual task rewards.; J Neurosci; 2009 Apr 15

Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T; Regulation of burst activity through presynaptic and postsynaptic GABA(B) receptors in mouse superior colliculus.; J Neurosci; 2008 Jan 23

Phongphanphanee P, Kaneda K, Isa T; Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording.; J Neurosci; 2008 Sep 10

Yoshida M, Takaura K, Kato R, Ikeda T, Isa T; Striate cortical lesions affect deliberate decision and control of saccade: implication for blindsight.; J Neurosci; 2008 Oct 15

Nishimura Y, Onoe T, Morichika Y, Perfiliev S, Tsukada H, Isa T (2007) Time-dependent central compensatory mechanism of finger dexterity after spinal-cord injury. Science, 318: 1150-1155.

Nishimura Y, Onoe H, Morichika Y, Perfiliev S, Tsukada H, Isa T; Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.; Science; 2007 Nov 16