Tadashi Isa
M.D.
Ph.D.
Professor
Bio
Tadashi Isa is a professor at Division of Physiology and Neurobiology, Department of Neuroscience and a chair of the Human Brain Research Center, Graduate School of Medicine, Kyoto University and heads the Isa Lab.
He aims at clarifying the neural circuit mechanims for the control of the dexterous movements of the hand and eyes, and related congive processes, and functional recovery of these functions after brain/spinal cord injury.
He aims at clarifying the neural circuit mechanims for the control of the dexterous movements of the hand and eyes, and related congive processes, and functional recovery of these functions after brain/spinal cord injury.
Research Interests
Neural circuit mechanism for the fine motor control such as dexterous hand movements and saccadic eye movements
Large-scaled network reorganization during recovery from spinal cord injury
Neural mechanism of blindsight
Local circuit mechanism of midbrain superior colliculus
Selected Publications
M. Sawada,
K. Kato,
T. Kunieda,
N. Mikuni,
S. Miyamoto,
H. Onoe,
T. Isa, and
Y. Nishimura
Function of the nucleus accumbens in motor control during recovery after spinal cord injury
Science,
350(6256),
2015
PUBMED
Projects
Contact
Address: Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, JAPAN
Email: isa.tadashi.7u@kyoto-u.ac.jp
Tel: 075-753-4351
Fax: 075-753-4349
Education
1985
Bachelor of Medicine, MD
Graduated from Faculty of Medicine, the University of Tokyo
1989
PhD
Finished PhD course of Graduate School of Medicine, the University of Tokyo, PhD Degree
Past Positions
1988-1990
Visiting Scientist
Department of Physiology, University of Gothenburgh, Sweden
1989-1993
Assistant Professor
Institute for Brain Research, Faculty of Medicine, the University of Tokyo
1993-1995
Lecturer
Department of Physiology, Medical School, Gunma University
1995-1995
Associate Professor
Department of Physiology, Medical School, Gunma University
1996-2004
Professor
National Institute for Physiological Sciences
2004-2015
Professor
National Institute for Physiological Sciences, National Institutes of Natural Sciences
2015-2017
Professor
Department of Neuroscience, Graduate School of Medicine, Kyoto University
2017-2017
Chair
Human Brain Research Center
Publications
2018
N. Higo,
A. Sato,
T. Yamamoto,
T. Oishi,
Y. Nishimura
Y. Murata,
H. Onoe
T. Isa
et al.
Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury.
Journal of Comparative Neurology,
256,
1110-1130,
2018
2017
T. Isa
Using the common marmoset for neurophysiological studies of neocortical functions.
Journal of Physiology,
595(7013),
2017
DOI
T. Isa
The brain is needed to cure spinal cord injury.
Trends in Neuroscience,
40,
625-636,
2017
N. Takakuwa,
R. Kato,
P. Redgrave, and
T. Isa
Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys.
eLife,
6,
2017
DOI
T. Yamamoto,
S. Murayama,
M. Takao,
T. Isa, and
N. Higo
Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis.
Brain Research,
1655,
168-175,
2017
T. Tohyama,
M. Kinoshita,
K. Kobayashi,
K. Isa,
D. Watanabe,
K. Kobayashi,
M. Liu, and
T. Isa
Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
Proceedings of National Academy of Science USA,
114,
604-609,
2017
2016
M. Kasai and
T. Isa
Imaging population dynamics of surround suppression in the superior colliculus.
Eur J Neurosci.,
44(8),
2543-2556,
2016
URL
DOI
K. Kobayashi,
H. Sano,
S. Kato,
K. Kuroda,
S. Nakamuta,
T. Isa
A. Nambu,
K. Kaibuchi,
et al.
Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway.
Neuroscience Letters,
630,
45-52,
2016
2015
O. Sadakane,
A. Watakabe,
M. Ohtsuka,
M. Takaji,
T. Sasaki,
M. Kasai
T. Isa
G. Kato,
et al.
In Vivo Two-Photon Imaging of Dendritic Spines in Marmoset Neocortex(1,2,3)
eNeuro,
2(4),
2015
URL
DOI
M. Sawada,
K. Kato,
T. Kunieda,
N. Mikuni,
S. Miyamoto,
H. Onoe,
T. Isa, and
Y. Nishimura
Function of the nucleus accumbens in motor control during recovery after spinal cord injury
Science,
350(6256),
2015
PUBMED
2012
M. Kinoshita,
R. Matsui,
S. Kato,
T. Hasegawa,
H. Kasahara,
K. Isa,
A. Watakabe,
T. Yamamori,
et al.
Genetic dissection of the circuit for hand dexterity in primates
Nature,
487(7406),
2012
2007
Y. Nishimura,
H. Onoe,
Y. Morichika,
S. Perfiliev,
H. Tsukada, and
T. Isa
Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury
Science,
318(5853),
2007
2004
B. Alstermark,
J. Ogawa, and
T. Isa
Lack of monosynaptic corticomotoneuronal EPSPs in rats: disynaptic EPSPs mediated via reticulospinal neurons and polysynaptic EPSPs via segmental interneurons
Journal of neurophysiology,
91(4),
2004
S. Sasaki,
T. Isa,
L.-G. Pettersson,
B. Alstermark,
K. Naito,
K. Yoshimura,
K. Seki, and
Y. Ohki
Dexterous finger movements in primate without monosynaptic corticomotoneuronal excitation
Journal of neurophysiology,
92(5),
2004
2002
T. Isa
Intrinsic processing in the mammalian superior colliculus
Current opinion in neurobiology,
12(6),
2002
1999
B. Alstermark,
T. Isa,
Y. Ohki, and
Y. Saito
Disynaptic Pyramidal Excitation in Forelimb Motoneurons Mediated Via C3--C4 Propriospinal Neurons in the Macaca fuscata
Journal of Neurophysiology,
82(6),
1999
1998
T. Isa,
T. Endo, and
Y. Saito
The visuo-motor pathway in the local circuit of the rat superior colliculus
Journal of Neuroscience,
18(20),
1998