Tadashi Isa
M.D.
Ph.D.
Professor
Bio
Tadashi Isa is a professor at Division of Physiology and Neurobiology, Department of Neuroscience and a chair of the Human Brain Research Center, Graduate School of Medicine, Kyoto University and heads the Isa Lab.

He aims at clarifying the neural circuit mechanims for the control of the dexterous movements of the hand and eyes, and related congive processes, and functional recovery of these functions after brain/spinal cord injury.
Research Interests

Neural circuit mechanism for the fine motor control such as dexterous hand movements and saccadic eye movements

Large-scaled network reorganization during recovery from spinal cord injury

Neural mechanism of blindsight

Local circuit mechanism of midbrain superior colliculus

Selected Publications
M. Sawada, K. Kato, T. Kunieda, N. Mikuni, S. Miyamoto, H. Onoe, T. Isa, and Y. Nishimura Function of the nucleus accumbens in motor control during recovery after spinal cord injury Science, 350(6256), 2015 PUBMED
Contact

Address: Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, JAPAN

Email: isa.tadashi.7u@kyoto-u.ac.jp

Tel: 075-753-4351

Fax: 075-753-4349

Education
1985
Bachelor of Medicine, MD
Graduated from Faculty of Medicine, the University of Tokyo
1989
PhD
Finished PhD course of Graduate School of Medicine, the University of Tokyo, PhD Degree
Past Positions
1988-1990
Visiting Scientist
Department of Physiology, University of Gothenburgh, Sweden
1989-1993
Assistant Professor
Institute for Brain Research, Faculty of Medicine, the University of Tokyo
1993-1995
Lecturer
Department of Physiology, Medical School, Gunma University
1995-1995
Associate Professor
Department of Physiology, Medical School, Gunma University
1996-2004
Professor
National Institute for Physiological Sciences
2004-2015
Professor
National Institute for Physiological Sciences, National Institutes of Natural Sciences
2015-2017
Professor
Department of Neuroscience, Graduate School of Medicine, Kyoto University
2017-2017
Chair
Human Brain Research Center
Publications

2018


N. Higo, A. Sato, T. Yamamoto, T. Oishi, Y. Nishimura Y. Murata, H. Onoe T. Isa et al. Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury. Journal of Comparative Neurology, 256, 1110-1130, 2018
Y. Yoshida and T. Isa Neural and genetic basis of dexterous hand movements. Current Opinion in Neurobiology, 23(52), 25-32, 2018 DOI

2017


T. Isa Using the common marmoset for neurophysiological studies of neocortical functions. Journal of Physiology, 595(7013), 2017 DOI
T. Isa The brain is needed to cure spinal cord injury. Trends in Neuroscience, 40, 625-636, 2017
N. Takakuwa, R. Kato, P. Redgrave, and T. Isa Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys. eLife, 6, 2017 DOI
T. Yamamoto, S. Murayama, M. Takao, T. Isa, and N. Higo Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis. Brain Research, 1655, 168-175, 2017
T. Tohyama, M. Kinoshita, K. Kobayashi, K. Isa, D. Watanabe, K. Kobayashi, M. Liu, and T. Isa Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys. Proceedings of National Academy of Science USA, 114, 604-609, 2017

2016


M. Kasai and T. Isa Imaging population dynamics of surround suppression in the superior colliculus. Eur J Neurosci., 44(8), 2543-2556, 2016 URL DOI
K. Kobayashi, H. Sano, S. Kato, K. Kuroda, S. Nakamuta, T. Isa A. Nambu, K. Kaibuchi, et al. Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway. Neuroscience Letters, 630, 45-52, 2016

2015


O. Sadakane, A. Watakabe, M. Ohtsuka, M. Takaji, T. Sasaki, M. Kasai T. Isa G. Kato, et al. In Vivo Two-Photon Imaging of Dendritic Spines in Marmoset Neocortex(1,2,3) eNeuro, 2(4), 2015 URL DOI
M. Sawada, K. Kato, T. Kunieda, N. Mikuni, S. Miyamoto, H. Onoe, T. Isa, and Y. Nishimura Function of the nucleus accumbens in motor control during recovery after spinal cord injury Science, 350(6256), 2015 PUBMED
R. Veale, T. Isa, and M. Yoshida Applying differential evolution mcmc to parameterize large-scale spiking neural simulations Evolutionary Computation (CEC), 2015 IEEE Congress on, 2015

2012


M. Kinoshita, R. Matsui, S. Kato, T. Hasegawa, H. Kasahara, K. Isa, A. Watakabe, T. Yamamori, et al. Genetic dissection of the circuit for hand dexterity in primates Nature, 487(7406), 2012

2007


Y. Nishimura, H. Onoe, Y. Morichika, S. Perfiliev, H. Tsukada, and T. Isa Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury Science, 318(5853), 2007

2004


B. Alstermark, J. Ogawa, and T. Isa Lack of monosynaptic corticomotoneuronal EPSPs in rats: disynaptic EPSPs mediated via reticulospinal neurons and polysynaptic EPSPs via segmental interneurons Journal of neurophysiology, 91(4), 2004
S. Sasaki, T. Isa, L.-G. Pettersson, B. Alstermark, K. Naito, K. Yoshimura, K. Seki, and Y. Ohki Dexterous finger movements in primate without monosynaptic corticomotoneuronal excitation Journal of neurophysiology, 92(5), 2004

2002


T. Isa Intrinsic processing in the mammalian superior colliculus Current opinion in neurobiology, 12(6), 2002

1999


B. Alstermark, T. Isa, Y. Ohki, and Y. Saito Disynaptic Pyramidal Excitation in Forelimb Motoneurons Mediated Via C3--C4 Propriospinal Neurons in the Macaca fuscata Journal of Neurophysiology, 82(6), 1999

1998


T. Isa, T. Endo, and Y. Saito The visuo-motor pathway in the local circuit of the rat superior colliculus Journal of Neuroscience, 18(20), 1998